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CBG for Pain & Inflammation

Guest Blog by: Joy Hughes, a writer of health, nutrition and all things cannabis. Having experienced the therapeutic effects of cannabinoids first hand, she's been spreading the word ever since. She currently travels the country in an RV with her husband and beloved beagle. Contact her at


What do joint and neck pain, muscle soreness, and persistent bloating all have in common? 

Answer: Inflammation.

In fact, according to scientific research, “The origin of all pain is inflammation”. And the key to reducing chronic pain is to target the response of inflammation. 

But let’s face it... Finding a natural, less invasive approach to addressing these ailments can be a bit overwhelming. 

Now, it’s safe to say that most people have heard of the amazing therapeutic properties of Cannabidiol (CBD), which has been shown to relieve inflammation and address pain. 

But there’s another cannabinoid scientists are now getting more intrigued with… it’s called Cannabigerol (CBG). 

That’s right, this cannabinoid seems to be gaining more attention and popularity for its potent therapeutic value.  

So what exactly is CBG? And why is this particular cannabinoid so magical? 

What is CBG?

In order to really understand what CBG is, we need to first look at the plant that it’s derived from: Cannabis sativa. 

Now, we understand this can be confusing to those who tend to refer to marijuana as “cannabis”.

But did you know that hemp and marijuana belong to the same genus of flowering plants? This means they’re both considered cannabis. 

Within the cannabis plant, over 100 cannabinoids have been discovered. And of these cannabinoids, we have: 

  • The infamous Tetrahydrocannabinol (THC)
  • The non-psychoactive Cannabidiol (CBD)
  • The third prominent Cannabichromene (CBC)
  • And the highly-sought after Cannabigerol (CBG)

CBG is considered the “mother of all cannabinoids,” because it serves as a precursor to them.

But because it plays such an important role in parenting these other cannabinoids, only very low amounts of CBG are detected in nearly all cannabis strains once they’re grown. 

This may explain why cultivators feel they’ve struck gold when they’re able to yield higher amounts of CBG through cross-breeding, or by extracting it from budding plants that aren’t yet mature.

But why are they so interested in CBG? 

What makes CBG so very different from the other, more prevalent, cannabinoids? 


CBG-A, CBD-A and THC-A are the molecules found in the plant. Through a process called decarboxylation, they become what you know as CBG, CBD and THC.


Difference between CBG and other cannabinoids 

In truth, CBD and THC clearly have more scientific studies to back their therapeutic value, whereas CBG has only a few studies under its belt. 

And while we can all agree that much more research is needed regarding any cannabinoid, scientists have suggested that CBG, in particular, interacts with our Endocannabinoid System (ECS) more effectively than CBD. 

It’s also been theorized that CBG may enhance the therapeutic properties of CBD. Which means those who don’t benefit much from CBD on its own, may find the combination more effective. 

But how? 

First, if you’re scratching your head, wondering what the Endocannabinoid System (ECS) is, don’t worry. This system wasn’t taught in your biology class. 

In fact, very few doctors even know about this amazing biological signaling system, which was only discovered in the 1970s. 

So to clear the air, this system is found in all mammals and it helps to communicate balance and regulation in and throughout the body. 

Now back to CBG… 

Similar to other cannabinoids, CBG imitates compounds in our bodies that we naturally produce called endocannabinoids, which activate to maintain homeostasis in the body. 

And as we just mentioned, the ECS is always looking to maintain balance. But believe it or not, cannabinoids like CBG and CBD can mediate communication between cells when there’s a deficiency or a problem in your body. This reintroduces balance within the body and can help address aches, pains, and even inflammation.

Now let’s look at how beneficial CBG really is…

Benefits of CBG 

As mentioned earlier, there aren’t a lot of studies regarding CBG yet, but the ones that have been conducted are profound and thought-provoking. Here’s a quick rundown of the findings… 

  • CBG and Glaucoma –– Many studies show that medical marijuana is quite effective in treating patients with glaucoma, but research shows CBG is a big part of it. In a 2008 study, researchers found that CBG was able to reduce intraocular pressure (inflammation), which is prevalent in glaucoma patients. 
  • CBG and Bladder disorders –– It’s been said that certain cannabinoids may help with bladder contractions (which are often brought on by inflammation). But in a 2015 study, researchers noted that one out of five various cannabinoids showed the most promise in treating bladder disorders and contractions. That cannabinoid was CBG! 
  • CBG and bacterial infections –– There are a lot of bacterial infections that are hard to treat and can even be deadly. Methicillin-resistant Staphylococcus aureus (MRSA) is one of them. In fact, this particular bacteria can cause drug-resistant staph infections. But in another 2008 study, researchers found that CBG was effective in killing MRSA. 
  • CBG and Cancer –– Cancer is always a touchy subject when it comes to natural remedies. But according to a 2014 study, scientists concluded that CBG may help reduce the growth of cancerous cells found in rats with colon cancer. 
  • CBG and Appetite –– Many medical treatments could cause decreased appetite, which may deplete the body of certain nutrients. In a 2016 study, scientists found that CBG may be able to stimulate a more healthy appetite in rats. 
  • CBG and Inflammatory Bowel Disease (IBD) –– In a 2013 study, researchers found that CBG is quite effective in reducing inflammation, especially in mice with IBD. 

Pretty amazing, right? 

But there’s a lot more to CBG than what the studies above demonstrate.

pain and inflammation

CBD for pain and inflammation

If you look at the studies mentioned above, you’ll see that inflammation is often a contributor or a symptom. And where there’s inflammation, there’s pain and other health problems.

But the most intriguing aspect of CBG is that it’s a powerful anti-inflammatory, antioxidant, and neuroprotectant.

These therapeutic properties make CBG particularly interesting given that inflammation and oxidative stress play a huge role in neurodegeneration — which results in chronic pain. 

Amazingly, according to research, CBG has shown the ability to regulate the release of GABA –– a neurotransmitter that helps calm pain, anxiety, depression, insomnia, and panic disorders.

In fact, CBG regulates GABA far greater than THC and CBD do, and scientists suggest that it may be used as a muscle relaxant for people with spasms. 

Research also suggests that CBG is a far more potent analgesic (pain reliever) than THC and even CBD.   

So does this mean that CBG is better than CBD? 

The truth is, some research indicates that CBG may actually be more effective and more potent than CBD. But more research is still needed on the matter. 

It does however mean that...

CBD is better with CBG

Scientists have a term for when multiple cannabinoids combine together to give your body a much greater effect than they could on their own. It’s called the Entourage Effect.

And here’s the best part… 

Like CBD, CBG is completely non-psychoactive. So it won’t get you “high,” but will rather offer your body a much more calming effect. 

Studies also confirm that CBG is well-tolerated among its users (though most of these studies involved animal models, rather than humans).


The bottom line for CBG and pain 

While the few studies we mentioned above showcase how beneficial CBG is, more studies and research are desperately needed. 

Still, there’s no denying that high-quality CBG products, especially when combined with premium CBD, may be the answer you're seeking. 

Maybe you’ve reached a point where you seem to constantly battle with pain, inflammation, insomnia, or some other health issue. And for a while now, you’ve been on the fence about taking hemp-derived cannabinoids like CBG and CBD. 

We understand the hesitancy and we commend you for doing your due diligence and researching these molecules before consuming them. (Note: As with any natural supplement, CBG and CBD are not “cure-all”molecules, and shouldn’t be used to diagnose, treat, or cure health conditions and diseases.)

However, it’s also worth mentioning that renowned doctors, scientists, and other medical professionals are finally acknowledging just how effective these cannabinoids can be. 

For this reason, if you’re curious about trying CBG, it’s best to purchase high-quality CBG and CBD products from reputable companies that focus on the following: 

  • Safety
  • Accuracy
  • Potency
  • Efficiency
  • Integrity

Here at Naternal, we do just that. 

We control the entire process from seed to shelf (something most companies can’t say). Our hemp is grown in the fertile soils of rural North Carolina, with a specific combination of cannabinoids, terpenes, and flavonoids. 

Our products are formulated by two of the world’s top natural product experts. And in our state-of-the-art cannabis manufacturing facility in the world-renowned Research Triangle, we meticulously produce every product before having them rigorously tested by an accredited third party facility. The result is something we’re proud to share with our families—and with yours.

If you have any questions, concerns, or comments, feel free to reach out to us here. We’d love to hear from you.

Shop Move CBD+CBG here!